{"id":11385,"date":"2025-05-26T15:24:17","date_gmt":"2025-05-26T13:24:17","guid":{"rendered":"https:\/\/www.kliinikum.ee\/yhendlabor\/?page_id=11385"},"modified":"2025-10-29T19:15:32","modified_gmt":"2025-10-29T17:15:32","slug":"vaga-pika-ahelaga-rasvhapped-seerumis","status":"publish","type":"page","link":"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/ainevahetushaiguste-uuringud\/vaga-pika-ahelaga-rasvhapped-seerumis\/","title":{"rendered":"V\u00e4ga pika ahelaga rasvhapped seerumis"},"content":{"rendered":"\n

Geneetika ja personaalmeditsiini kliinik, laboratoorse geneetika osakond, ainevahetuslabor, tel. 731 9485, www.kliinikum.ee\/geneetika\/<\/a><\/em><\/p>\n\n\n\n

V\u00e4ga pika ahelaga rasvhapete<\/strong> (C24<\/sub>\u2013C26<\/sub> ahela pikkusega rasvhapped) ja hargneva ahelaga rasvhapete (f\u00fctaanhape) kvantitatiivset anal\u00fc\u00fcsi kasutatakse peroks\u00fcsomaalsete haiguste esmaseks diagnostikaks. K\u00f5ik m\u00e4\u00e4ratavad v\u00e4ga pika ahelaga v\u00f5i hargneva ahelaga rasvhapped osalevad peroks\u00fcsomaalses beetaoks\u00fcdatsiooni protsessis. Nad on organismis kas lipiidide v\u00f5i valguga seotud, mist\u00f5ttu neid saab m\u00e4\u00e4rata ainult seerumist ja mitte uriinist.<\/p>\n\n\n\n

Peroks\u00fcsomaalne ainevahetus on stabiilne ja ei ole m\u00f5jutatav toitumisest, n\u00e4lgimisest v\u00f5i f\u00fc\u00fcsilisest koormusest. Erandiks on f\u00fctaanhappe ainevahetus, sest f\u00fctaanhapet saadakse peamiselt toidust ja seda sisaldavate toiduainete (loomaliha ja rasvad) s\u00f6\u00f6mine v\u00f5ib m\u00f5jutada anal\u00fc\u00fcsi tulemust.<\/p>\n\n\n\n

Peroks\u00fcsomaalsete haiguste esmane kahtlus tekib kliinilise pildi alusel. Patsiendil v\u00f5ivad esineda iseloomulikud tunnused nagu d\u00fcsmorfne n\u00e4gu, laialt avatud suur l\u00f5ge, v\u00e4ljendunud lihash\u00fcpotoonia, maksakahjustus ja neeru ts\u00fcstid. Need on iseloomulikeks tunnusteks just klassikalisele perok\u00fcsomaalsele haigusele \u2013 Zellwegeri s\u00fcndroomile. Risomeelse t\u00e4pja kondrod\u00fcsplaasia (rhizomelic chondrodysplasia punctata<\/em>) korral esineb ka d\u00fcsproportsionaalne kasvupeetus, mis meenutab teisi kondrod\u00fcstroofiaid. Kergematel juhtudel v\u00f5ib aga esineda ainult pigmentretiniit ja\/v\u00f5i kuulmise langus.<\/p>\n\n\n\n

Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine<\/strong><\/p>\n\n\n\n

Soovitav on proov anda hommikul t\u00fchja k\u00f5huga.<\/p>\n\n\n\n

<\/td>Katsuti<\/strong><\/td>Geeli ja h\u00fc\u00fcbimisaktivaatoriga katsuti (punane kollase r\u00f5ngaga kork v\u00f5i kollane kork)<\/td><\/tr>
<\/td>Anal\u00fc\u00fcsitav kogus<\/strong><\/td>0,5\u20131 mL seerumit<\/td><\/tr>
<\/td>S\u00e4ilivus<\/strong><\/td>Seerum toatemperatuuril 2\u20134 tundi, +4 \u00b0C 15 p\u00e4eva, -20 \u00b0C 92 p\u00e4eva<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Anal\u00fc\u00fcsi tegemise aeg: <\/strong>t\u00f6\u00f6p\u00e4eviti, proovide ettevalmistamine ja tulemuste hindamine toimub geneetika ja personaalmeditsiini kliinikus, anal\u00fc\u00fcs teostatakse Terviseameti Rahvatervise laboris. Uuringu valmimisaeg kuni neli n\u00e4dalat alates laborisse saabumise kuup\u00e4evast. Cito<\/em> anal\u00fc\u00fcsi korral saab vastuse 1\u20132 t\u00f6\u00f6p\u00e4eva jooksul.<\/p>\n\n\n\n

Anal\u00fc\u00fcsimeetod: <\/strong>gaaskromatograafia-massispektromeetria (GC\/MS)<\/p>\n\n\n\n

Referentsv\u00e4\u00e4rtused<\/strong><\/p>\n\n\n\n

Igale vastusele lisatakse eraldi vastavad referentsv\u00e4\u00e4rtused ja interpretatsioon.<\/p>\n\n\n\n

<\/td> <\/td>< 4 k<\/strong><\/td>4 k \u2013 < 8 k<\/strong><\/td>8 k \u2013 < 1 a<\/strong><\/td>1 a \u2013 < 2 a<\/strong><\/td>\u2265 2 a<\/strong><\/td><\/tr>
<\/td>Pristaanhape (\u00b5mol\/L)<\/td>0,01\u20130,6<\/td>0,01\u20130,84<\/td>0,01\u20130,77<\/td>0,12\u20131,47<\/td>0,12\u20132,98<\/td><\/tr>
<\/td>F\u00fctaanhape (\u00b5mol\/L)<\/td>0,04\u20135,28<\/td>0,21\u20135,7<\/td>0,38\u20134,4<\/td>1,34\u20138,62<\/td>0,49\u20139,88<\/td><\/tr>
<\/td>C22 (\u00b5mol\/L)<\/td>40\u2013119<\/td>40\u2013119<\/td>40\u2013119<\/td>40\u2013119<\/td>40\u2013119<\/td><\/tr>
<\/td>C24 (\u00b5mol\/L)<\/td>33\u201384<\/td>33\u201384<\/td>33\u201384<\/td>33\u201384<\/td>33\u201384<\/td><\/tr>
<\/td>C26 (\u00b5mol\/L)<\/td>0,45\u20131,32<\/td>0,45\u20131,32<\/td>0,45\u20131,32<\/td>0,45\u20131,32<\/td>0,45\u20131,32<\/td><\/tr>
<\/td>C24\/C22<\/td>0,57\u20130,92<\/td>0,57\u20130,92<\/td>0,57\u20130,92<\/td>0,57\u20130,92<\/td>0,57\u20130,92<\/td><\/tr>
<\/td>C26\/C22<\/td>0,01\u20130,02<\/td>0,01\u20130,02<\/td>0,01\u20130,02<\/td>0,01\u20130,02<\/td>0,01\u20130,02<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

N\u00e4idustus ja kliiniline t\u00e4hendus<\/strong><\/p>\n\n\n\n

Peroks\u00fcsomaalsete haiguste esmane diagnostika.<\/p>\n\n\n\n

Suurenenud v\u00e4ga pika ahelaga rasvhapete sisaldus viitab p\u00e4rilikele peroks\u00fcsomaalsetele haigustele nagu Zellwegeri s\u00fcndroom, neonataalne adrenoleukod\u00fcstroofia, risomeelne t\u00e4pjas kondrod\u00fcsplaasia jt. Refsumi t\u00f5ve ja risomeelse t\u00e4pja kondrod\u00fcsplaasia korral esineb ainult f\u00fctaanhappe sisalduse suurenemine. L\u00f5plik diagnoosi kinnitamine toimub ens\u00fc\u00fcmanal\u00fc\u00fcsi abil.<\/p>\n\n\n\n

Mitteperoks\u00fcsomaalse p\u00e4ritoluga v\u00e4ga pika ahelaga rasvhapete sisalduse suurenemist seerumis esineb v\u00e4ga harva.<\/p>\n\n\n\n

Koostajad: Katrin \u00d5unap, Kadi K\u00fcnnapas
Muudetud 25.05.2023<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Geneetika ja personaalmeditsiini kliinik, laboratoorse geneetika osakond, ainevahetuslabor, tel. 731 9485, www.kliinikum.ee\/geneetika\/ V\u00e4ga pika ahelaga rasvhapete (C24\u2013C26 ahela pikkusega rasvhapped) ja hargneva ahelaga rasvhapete (f\u00fctaanhape) kvantitatiivset anal\u00fc\u00fcsi kasutatakse peroks\u00fcsomaalsete haiguste esmaseks diagnostikaks. K\u00f5ik m\u00e4\u00e4ratavad v\u00e4ga pika ahelaga v\u00f5i hargneva ahelaga rasvhapped osalevad peroks\u00fcsomaalses beetaoks\u00fcdatsiooni protsessis. Nad on organismis kas lipiidide v\u00f5i valguga seotud, mist\u00f5ttu neid […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":7015,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-11385","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nV\u00e4ga pika ahelaga rasvhapped seerumis - \u00dchendlabor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/ainevahetushaiguste-uuringud\/vaga-pika-ahelaga-rasvhapped-seerumis\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"V\u00e4ga pika ahelaga rasvhapped seerumis - \u00dchendlabor\" \/>\n<meta property=\"og:description\" content=\"Geneetika ja personaalmeditsiini kliinik, laboratoorse geneetika osakond, ainevahetuslabor, tel. 731 9485, www.kliinikum.ee\/geneetika\/ V\u00e4ga pika ahelaga rasvhapete (C24\u2013C26 ahela pikkusega rasvhapped) ja hargneva ahelaga rasvhapete (f\u00fctaanhape) kvantitatiivset anal\u00fc\u00fcsi kasutatakse peroks\u00fcsomaalsete haiguste esmaseks diagnostikaks. 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