{"id":11426,"date":"2025-05-26T17:06:05","date_gmt":"2025-05-26T15:06:05","guid":{"rendered":"https:\/\/www.kliinikum.ee\/yhendlabor\/?page_id=11426"},"modified":"2025-12-21T17:42:38","modified_gmt":"2025-12-21T15:42:38","slug":"koe-transglutaminaasi-vastased-iga-ja-igg-s-ttg-iga-s-ttg-igg","status":"publish","type":"page","link":"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/autoimmuunuuringud\/koe-transglutaminaasi-vastased-iga-ja-igg-s-ttg-iga-s-ttg-igg\/","title":{"rendered":"Koe transglutaminaasi vastased IgA ja IgG (S-tTG IgA, S-tTG IgG)"},"content":{"rendered":"\n

Immuunanal\u00fc\u00fcsi osakond<\/em><\/p>\n\n\n\n

Koe transglutaminaas (tissue transglutaminase,<\/em> tTG)<\/em><\/strong> on kaltsiumist s\u00f5ltuv ens\u00fc\u00fcm molekulmassiga 85 kDa, mis katal\u00fc\u00fcsib isopeptiidsidemete moodustamist glutamiini ja l\u00fcsiini j\u00e4\u00e4kide vahel. Olles ekspresseeritud erinevates kudedes ja rakut\u00fc\u00fcpides, osaleb tTG mitmetes f\u00fcsioloogilistes protsessides, nagu rakkude diferentseerumine, apoptoos ning ekstratsellulaarse maatriksi kujunemine. Lokaalset tTG aktiivsuse muutust on t\u00e4heldatud mitmete krooniliste p\u00f5letikuliste haiguste puhul. Ts\u00f6liaakia e gluteenenteropaatia korral esinevad seerumis IgA ja\/v\u00f5i IgG t\u00fc\u00fcpi tTG vastased autoantikehad (anti-tissue transglutaminase antibodies<\/em>), olles ts\u00f6liaakiale spetsiifiliseks ja tundlikuks haigusmarkeriks.<\/p>\n\n\n\n

Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine<\/strong><\/p>\n\n\n\n

<\/td>Katsuti<\/strong><\/td> Geeli ja h\u00fc\u00fcbimisaktivaatoriga katsuti (kollane kork)<\/td><\/tr>
<\/td>S\u00e4ilivus<\/strong><\/td> Seerum +4 \u00b0C kaks p\u00e4eva, -20 \u00b0C paar kuud<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Anal\u00fc\u00fcsi tegemise aeg: <\/strong>kord n\u00e4dalas<\/p>\n\n\n\n

Anal\u00fc\u00fcsimeetod: <\/strong>fluorestsents-ens\u00fc\u00fcm-immuunmeetod (FEIA)<\/p>\n\n\n\n

Referentsv\u00e4\u00e4rtused<\/strong><\/p>\n\n\n\n

tTG-IgA<\/strong><\/p>\n\n\n\n

<\/td>< 7 kU\/L<\/strong><\/td>negatiivne<\/td><\/tr>
<\/td>7\u201310 kU\/L<\/strong><\/td>piiripealne<\/td><\/tr>
<\/td>\u2265 10 kU\/L<\/strong><\/td>positiivne<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

tTG-IgG<\/strong><\/p>\n\n\n\n

<\/td>< 7 kU\/L<\/strong><\/td>negatiivne<\/td><\/tr>
<\/td>7\u201310 kU\/L<\/strong><\/td>piiripealne<\/td><\/tr>
<\/td>> 10 kU\/L<\/strong><\/td>positiivne<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

N\u00e4idustus ja kliiniline t\u00e4hendus<\/strong><\/p>\n\n\n\n

Peamiselt gluteenenteropaatia (ts\u00f6liaakia) diagnostika ning ts\u00f6liaakia ravi efektiivsuse hindamine.<\/p>\n\n\n\n

Soovitav on m\u00e4\u00e4rata seerumis samaaegselt ka IgA ja IgG t\u00fc\u00fcpi deamideeritud gliadiini vastased antikehad.<\/p>\n\n\n\n

tTG IgA testi diagnostiline tundlikkus ts\u00f6liaakiale on 85\u201395% ning spetsiifilisus 91\u201396%. T\u00e4iendavaks v\u00f5i alternatiivseks testiks tTG IgA-le on EmA IgA, mille spetsiifilisus ts\u00f6liaakiale on veelgi k\u00f5rgem. Isikutel, kellel esineb selektiivne IgA puudulikkus ja tTG IgA test j\u00e4\u00e4b negatiivseks, on oluline m\u00e4\u00e4rata tTG IgG.<\/p>\n\n\n\n

Vt ka:\u00a0Gliadiinivastased IgA ja IgG<\/a><\/p>\n\n\n\n

Koostaja: Kaja Metsk\u00fcla
Muudetud 02.06.2016<\/p>\n","protected":false},"excerpt":{"rendered":"

Immuunanal\u00fc\u00fcsi osakond Koe transglutaminaas (tissue transglutaminase, tTG) on kaltsiumist s\u00f5ltuv ens\u00fc\u00fcm molekulmassiga 85 kDa, mis katal\u00fc\u00fcsib isopeptiidsidemete moodustamist glutamiini ja l\u00fcsiini j\u00e4\u00e4kide vahel. Olles ekspresseeritud erinevates kudedes ja rakut\u00fc\u00fcpides, osaleb tTG mitmetes f\u00fcsioloogilistes protsessides, nagu rakkude diferentseerumine, apoptoos ning ekstratsellulaarse maatriksi kujunemine. Lokaalset tTG aktiivsuse muutust on t\u00e4heldatud mitmete krooniliste p\u00f5letikuliste haiguste puhul. Ts\u00f6liaakia e […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":7253,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-11426","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nKoe transglutaminaasi vastased IgA ja IgG (S-tTG IgA, S-tTG IgG) - \u00dchendlabor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/autoimmuunuuringud\/koe-transglutaminaasi-vastased-iga-ja-igg-s-ttg-iga-s-ttg-igg\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Koe transglutaminaasi vastased IgA ja IgG (S-tTG IgA, S-tTG IgG) - \u00dchendlabor\" \/>\n<meta property=\"og:description\" content=\"Immuunanal\u00fc\u00fcsi osakond Koe transglutaminaas (tissue transglutaminase, tTG) on kaltsiumist s\u00f5ltuv ens\u00fc\u00fcm molekulmassiga 85 kDa, mis katal\u00fc\u00fcsib isopeptiidsidemete moodustamist glutamiini ja l\u00fcsiini j\u00e4\u00e4kide vahel. 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