{"id":12067,"date":"2025-07-01T17:32:28","date_gmt":"2025-07-01T15:32:28","guid":{"rendered":"https:\/\/www.kliinikum.ee\/yhendlabor\/?page_id=12067"},"modified":"2025-11-26T18:45:50","modified_gmt":"2025-11-26T16:45:50","slug":"koorioni-gonadotropiin-sp-hcg","status":"publish","type":"page","link":"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/hormoonid-jm-immuunuuringud\/koorioni-gonadotropiin-sp-hcg\/","title":{"rendered":"Koorioni gonadotropiin (S,P-hCG)"},"content":{"rendered":"\n

Kliinilise keemia ja laboratoorse hematoloogia osakond<\/em><\/p>\n\n\n\n

Koorioni gonadotropiin (hCG)<\/strong> on gl\u00fckoproteiin, mida s\u00fcnteesitakse \u00fcldreeglina platsentas, aga ka m\u00f5ningate kasvajate poolt. hCG koosneb kahest ala\u00fchikust, neist \u03b1-ala\u00fchik on sarnane h\u00fcpof\u00fc\u00fcsi hormoonides (FSH, LH, TSH) leiduvatele, \u03b2-ala\u00fchik on hCG-le spetsiifiline, kuid ei erine v\u00e4ga palju luteiniseeriva hormooni (LH) \u03b2-ala\u00fchikust. hCG on vajalik progesterooni s\u00fcnteesi induktsiooniks kollaskehas, seni kuni progesterooni hakkab s\u00fcnteesima platsenta, ning loote sugun\u00e4\u00e4rmete arenguks. hCG tase t\u00f5useb v\u00e4ga kiiresti raseduse esimesel trimestril (kahekordistub iga kahe p\u00e4evaga), maksimaalne on kontsentratsioon 7.\u201311. rasedusn\u00e4dalal (kuni 300 000 IU\/L), v\u00e4henedes veerandini sellest viimasel trimestril ning p\u00fcsides stabiilsena kuni s\u00fcnnituseni. hCG eritub uriiniga, kontsentratsioon uriinis on samas suurusj\u00e4rgus kui seerumis.<\/p>\n\n\n\n

Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine<\/strong><\/p>\n\n\n\n

<\/td>Katsuti<\/strong><\/td>Geeli ja h\u00fc\u00fcbimisaktivaatoriga katsuti (punane kollase r\u00f5ngaga v\u00f5i kollane kork), geeliga LH-katsuti (roheline kollase r\u00f5ngaga v\u00f5i heleroheline kork)<\/td><\/tr>
<\/td>S\u00e4ilivus<\/strong><\/td>Seerum toatemperatuuril viis p\u00e4eva, +4 \u00b0C kaks n\u00e4dalat, -20 \u00b0C \u00fcks aasta<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Anal\u00fc\u00fcsi tegemise aeg:<\/strong> \u00f6\u00f6p\u00e4evaringselt<\/p>\n\n\n\n

Anal\u00fc\u00fcsimeetod: <\/strong>elektrokemoluminestsents-immuunmeetod (ECLIA)<\/p>\n\n\n\n

Referentsv\u00e4\u00e4rtused<\/strong><\/p>\n\n\n\n

<\/td>M \u2265 18 a<\/strong><\/td><\/td>< 2,0 IU\/L<\/td><\/tr>
<\/td>N (mitterasedad)<\/strong><\/td><\/td>\u2264 1,0 IU\/L<\/td><\/tr>
<\/td>N rasedad\u00a0<\/strong><\/td>3. n\u00e4dal<\/strong><\/td>5,8\u201371,2 IU\/L<\/td><\/tr>
<\/td><\/td>4. n\u00e4dal<\/strong><\/td>9,5\u2013750 IU\/L<\/td><\/tr>
<\/td><\/td>5. n\u00e4dal<\/strong><\/td>217\u20137138 IU\/L<\/td><\/tr>
<\/td><\/td>6. n\u00e4dal<\/strong><\/td>158\u201331795 IU\/L<\/td><\/tr>
<\/td><\/td>7. n\u00e4dal<\/strong><\/td>3697\u2013163563 IU\/L<\/td><\/tr>
<\/td><\/td>8. n\u00e4dal<\/strong><\/td>32065\u2013149571 IU\/L<\/td><\/tr>
<\/td><\/td>9. n\u00e4dal<\/strong><\/td>63803\u2013151410 IU\/L<\/td><\/tr>
<\/td><\/td>10. n\u00e4dal<\/strong><\/td>46509\u2013186977 IU\/L<\/td><\/tr>
<\/td><\/td>12. n\u00e4dal<\/strong><\/td>27832\u2013210612 IU\/L<\/td><\/tr>
<\/td><\/td>14. n\u00e4dal<\/strong><\/td>13950\u201362530 IU\/L<\/td><\/tr>
<\/td><\/td>15. n\u00e4dal<\/strong><\/td>12039\u201370971 IU\/L<\/td><\/tr>
<\/td><\/td>16. n\u00e4dal<\/strong><\/td>9040\u201356451 IU\/L<\/td><\/tr>
<\/td><\/td>17. n\u00e4dal<\/strong><\/td>8175\u201355868 IU\/L<\/td><\/tr>
<\/td><\/td>18. n\u00e4dal<\/strong><\/td>8099\u201358176 IU\/L<\/td><\/tr>
<\/td>N (postmenopaus)<\/strong><\/td><\/td>\u2264 7,0 IU\/L<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

N\u00e4idustus ja kliiniline t\u00e4hendus<\/strong><\/p>\n\n\n\n

Raseduse varajane tuvastamine. Lisauuring trofoblasti haiguste ja munandi ning munasarja idurakuliste kasvajate diagnostikas, ravi efektiivsuse ja haiguskulu j\u00e4lgimisel ning prognoosi m\u00e4\u00e4ramisel.<\/p>\n\n\n\n

Normaalse emakasisese raseduse korral kahekordistub hCG kontsentratsioon iga kahe p\u00e4evaga, saavutades maksimumi 7.\u201311. rasedusn\u00e4dalal. Ektoopilise raseduse korral on hCG produktsioon enamasti madalam ning t\u00f5useb aeglasemalt (v\u00f5i ebaregulaarselt) kui normaalse emakasisese raseduse ajal. P\u00e4rast s\u00fcnnitust normaliseerub hCG tase 2\u20133 n\u00e4dalaga; hCG taseme pikemaajaline p\u00fcsimine s\u00fcnnituse j\u00e4rgselt viitab platsenta retensioonile emakas. Loote kromosoomihaiguste (peamiselt Downi ja Edwardsi s\u00fcndroom) korral on hCG sisaldus raseda vereseerumis k\u00f5rgem v\u00f5rreldes normaalse rasedusega.<\/p>\n\n\n\n

Trofoblasti haiguste (p\u00f5ismool, koriokartsinoom) puhul on hCG produktsioon v\u00e4ga k\u00f5rge (500 000\u20131 000 000 IU\/L), kusjuures tase t\u00f5useb ka raseduse teisel poolel.<\/p>\n\n\n\n

V\u00e4ga k\u00f5rged hCG kontsentratsioonid v\u00f5ivad esineda ka idurakkudest p\u00e4rit koriokartsinoomi korral, aga ka embr\u00fconaalkartsinoomi, seminoomi ja segat\u00fc\u00fcpi idurakuliste kasvajate korral. Seminoomidest v\u00f5ivad 10\u201330% produtseerida ainult koorioni gonadotropiini vaba beetaala\u00fchikut (f\u00df-hCG).<\/p>\n\n\n\n

Munandi idurakulise v\u00e4hi korral on hCG v\u00f5i f\u00df-hCG koos alfafetoproteiini (AFP) ning laktaadi deh\u00fcdrogenaasiga (LDH) olulised prognostilised faktorid, mis toetavad nii diagnoosimist kui ka staadiumi m\u00e4\u00e4ramist. Seerummarkerid tuleb m\u00e4\u00e4rata enne ravi ja uuesti p\u00e4rast ravi, j\u00e4lgides markerite poolv\u00e4\u00e4rtusaegu. Kasvaja t\u00e4ielikul eemaldamisel peaks hCG tase langema referentsvahemikku arvestusega, et hCG poolv\u00e4\u00e4rtusaeg on 1,5 p\u00e4eva. Keemiaravi 1. n\u00e4dalal v\u00f5ib esineda l\u00fchiajalist hCG taseme (iatrogeenset) t\u00f5usu.<\/p>\n\n\n\n

T\u00f5usnud hCG + f\u00df-hCG taset on t\u00e4heldatud ka munasarja, gastrointestinaaltrakti, p\u00f5ie, kopsu jt kasvajate korral. Madalas kontsentratsioonis v\u00f5ib see olla leitav autoimmuunhaiguste korral. M\u00f5\u00f5dukat hCG taseme t\u00f5usu p\u00f5hjustab neerupuudulikkus.<\/p>\n\n\n\n

Koostaja: Kaja Vaagen
Muudetud 06.09.2023<\/p>\n","protected":false},"excerpt":{"rendered":"

Kliinilise keemia ja laboratoorse hematoloogia osakond Koorioni gonadotropiin (hCG) on gl\u00fckoproteiin, mida s\u00fcnteesitakse \u00fcldreeglina platsentas, aga ka m\u00f5ningate kasvajate poolt. hCG koosneb kahest ala\u00fchikust, neist \u03b1-ala\u00fchik on sarnane h\u00fcpof\u00fc\u00fcsi hormoonides (FSH, LH, TSH) leiduvatele, \u03b2-ala\u00fchik on hCG-le spetsiifiline, kuid ei erine v\u00e4ga palju luteiniseeriva hormooni (LH) \u03b2-ala\u00fchikust. hCG on vajalik progesterooni s\u00fcnteesi induktsiooniks kollaskehas, seni […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":7271,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-12067","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nKoorioni gonadotropiin (S,P-hCG) - \u00dchendlabor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/hormoonid-jm-immuunuuringud\/koorioni-gonadotropiin-sp-hcg\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Koorioni gonadotropiin (S,P-hCG) - \u00dchendlabor\" \/>\n<meta property=\"og:description\" content=\"Kliinilise keemia ja laboratoorse hematoloogia osakond Koorioni gonadotropiin (hCG) on gl\u00fckoproteiin, mida s\u00fcnteesitakse \u00fcldreeglina platsentas, aga ka m\u00f5ningate kasvajate poolt. hCG koosneb kahest ala\u00fchikust, neist \u03b1-ala\u00fchik on sarnane h\u00fcpof\u00fc\u00fcsi hormoonides (FSH, LH, TSH) leiduvatele, \u03b2-ala\u00fchik on hCG-le spetsiifiline, kuid ei erine v\u00e4ga palju luteiniseeriva hormooni (LH) \u03b2-ala\u00fchikust. hCG on vajalik progesterooni s\u00fcnteesi induktsiooniks kollaskehas, seni […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/hormoonid-jm-immuunuuringud\/koorioni-gonadotropiin-sp-hcg\/\" \/>\n<meta property=\"og:site_name\" content=\"\u00dchendlabor\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-26T16:45:50+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutit\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.kliinikum.ee\\\/yhendlabor\\\/kasiraamat\\\/hormoonid-jm-immuunuuringud\\\/koorioni-gonadotropiin-sp-hcg\\\/\",\"url\":\"https:\\\/\\\/www.kliinikum.ee\\\/yhendlabor\\\/kasiraamat\\\/hormoonid-jm-immuunuuringud\\\/koorioni-gonadotropiin-sp-hcg\\\/\",\"name\":\"Koorioni gonadotropiin (S,P-hCG) - 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