{"id":13868,"date":"2025-11-09T17:53:52","date_gmt":"2025-11-09T15:53:52","guid":{"rendered":"https:\/\/www.kliinikum.ee\/yhendlabor\/?page_id=13868"},"modified":"2025-11-09T17:53:56","modified_gmt":"2025-11-09T15:53:56","slug":"hepariini-pf4-kompleksi-vastased-antikehad-s-hep-pf4-ab","status":"publish","type":"page","link":"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/huubimisuuringud\/hepariini-pf4-kompleksi-vastased-antikehad-s-hep-pf4-ab\/","title":{"rendered":"Hepariini\/PF4 kompleksi vastased antikehad (S-Hep\/PF4 Ab)"},"content":{"rendered":"\n<p><em>Kliinilise keemia ja laboratoorse hematoloogia osakond<\/em><\/p>\n\n\n\n<p><strong>Hepariinist indutseeritud trombots\u00fctopeenial (HIT)<\/strong> on kaks vormi:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T\u00fc\u00fcp I \u2013 trombots\u00fc\u00fcdid agregeerivad hepariini toimel, tekib kerge m\u00f6\u00f6duv trombots\u00fctopeenia (trombots\u00fc\u00fctide arv tavaliselt > 100 x 10<sup>9<\/sup>\/L), algus 2\u20133 p\u00e4eva peale ravi algust, trombots\u00fc\u00fctide arv taastub peale hepariinravi katkestamist 2-3 p\u00e4evaga.<\/li>\n\n\n\n<li>T\u00fc\u00fcp II \u2013 tekivad IgG antikehad hepariini ja trombots\u00fc\u00fctide faktor 4 kompleksi (Hep\/PF4) vastu. Trombots\u00fc\u00fcdi pinnal toimuva immunoloogilise reaktsiooni tulemusena tekivad trombots\u00fctopeenia (trombots\u00fc\u00fctide arv tavaliselt &lt; 100 x 10<sup>9<\/sup>\/L) ja trombots\u00fc\u00fctide aktivatsioon. T\u00fc\u00fcp II seostub k\u00f5rge trombembooliliste komplikatsioonide riskiga (nii venoossed kui arteriaalsed tromboosid). Seisund kujuneb 5\u201314 p\u00e4eva p\u00e4rast ravi algust fraktsioneerimata hepariiniga, harva v\u00f5ib p\u00f5hjuseks olla ka ravi madalmolekulaarse hepariiniga. Antikehad kaovad 2\u20133 kuud p\u00e4rast hepariinravi l\u00f5petamist. Trombots\u00fc\u00fctide arv hakkab t\u00f5usma 2\u20133 p\u00e4eva peale hepariinravi l\u00f5petamist ja normaliseerub 10\u201314 p\u00e4evaga. Trombembooliliste komplikatsioonide risk p\u00fcsib k\u00f5rgem veel isegi peale antikehade kadumist.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-medium-font-size\"><strong>Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table width=\"100%\"><tbody><tr><td width=\"1%\"><\/td><td width=\"15%\"><strong>Katsuti<\/strong><\/td><td width=\"84%\">9NC-katsuti (helesinine kork)<\/td><\/tr><tr><td><\/td><td><strong>S\u00e4ilivus<\/strong><\/td><td>Plasma +4 \u00baC \u00fcks \u00f6\u00f6p\u00e4ev, -20 \u00baC 20 kuud. Plasma tuleb eraldada kahe tunni jooksul peale vere v\u00f5tmist (tsentrifuugida 2000\u20132500 g juures 15 min).<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><strong>Anal\u00fc\u00fcsi tegemise aeg: <\/strong>\u00f6\u00f6p\u00e4evaringselt<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong>Anal\u00fc\u00fcsimeetod: <\/strong>immuunkromatograafiline meetod<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong>Vastuse vorm<\/strong><\/p>\n\n\n\n<p>Positiivne\/negatiivne<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong>N\u00e4idustus ja kliiniline t\u00e4hendus<\/strong><\/p>\n\n\n\n<p>Hep\/PF4 antikehi m\u00e4\u00e4ratakse HIT kahtluse korral.<\/p>\n\n\n\n<p>Negatiivne tulemus v\u00e4listab HIT diagnoosi, positiivne tulemus ei kinnita HIT diagnoosi (anal\u00fc\u00fcsi spetsiifilisus ja positiivne ennustusj\u00f5ud on madalad). Uuringut on soovitav teha ainult HIT-i k\u00f5rge kliinilise riskiskoori korral.<\/p>\n\n\n\n<p>Oluline on m\u00e4\u00e4rata trombots\u00fc\u00fctide arv enne hepariinravi algust ja korduvalt ravi ajal. HIT-i korral esineb m\u00e4rgatav trombots\u00fc\u00fctide arvu v\u00e4henemine (&gt; 50%).<\/p>\n\n\n\n<p>Koostaja: Kaja Vaagen<br>Muudetud 08.08.2022<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kliinilise keemia ja laboratoorse hematoloogia osakond Hepariinist indutseeritud trombots\u00fctopeenial (HIT) on kaks vormi: Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine Katsuti 9NC-katsuti (helesinine kork) S\u00e4ilivus Plasma +4 \u00baC \u00fcks \u00f6\u00f6p\u00e4ev, -20 \u00baC 20 kuud. Plasma tuleb eraldada kahe tunni jooksul peale vere v\u00f5tmist (tsentrifuugida 2000\u20132500 g juures 15 min). Anal\u00fc\u00fcsi tegemise aeg: \u00f6\u00f6p\u00e4evaringselt Anal\u00fc\u00fcsimeetod: immuunkromatograafiline [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":7274,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-13868","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hepariini\/PF4 kompleksi vastased antikehad (S-Hep\/PF4 Ab) - \u00dchendlabor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/huubimisuuringud\/hepariini-pf4-kompleksi-vastased-antikehad-s-hep-pf4-ab\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepariini\/PF4 kompleksi vastased antikehad (S-Hep\/PF4 Ab) - \u00dchendlabor\" \/>\n<meta property=\"og:description\" content=\"Kliinilise keemia ja laboratoorse hematoloogia osakond Hepariinist indutseeritud trombots\u00fctopeenial (HIT) on kaks vormi: Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine Katsuti 9NC-katsuti (helesinine kork) S\u00e4ilivus Plasma +4 \u00baC \u00fcks \u00f6\u00f6p\u00e4ev, -20 \u00baC 20 kuud. 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