{"id":15578,"date":"2026-04-20T07:39:16","date_gmt":"2026-04-20T05:39:16","guid":{"rendered":"https:\/\/www.kliinikum.ee\/yhendlabor\/?page_id=15578"},"modified":"2026-04-20T08:11:54","modified_gmt":"2026-04-20T06:11:54","slug":"neuronaalsete-antigeenide-igg-paneel-ib","status":"publish","type":"page","link":"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/autoimmuunuuringud\/neuronaalsete-antigeenide-igg-paneel-ib\/","title":{"rendered":"Neuronaalsete antigeenide IgG paneel (IB)"},"content":{"rendered":"\n

Immuunanal\u00fc\u00fcsi osakond<\/em><\/p>\n\n\n\n

Anal\u00fc\u00fcsid:<\/h4>\n\n\n\n
<\/td>Ri IgG<\/td><\/tr>
<\/td>CV2 (CRMP5) IgG<\/td><\/tr>
<\/td>Sox1 IgG<\/td><\/tr>
<\/td>GAD65 IgG<\/td><\/tr>
<\/td>Hu IgG <\/td><\/tr>
<\/td>PNMA-2 (Ma2\/Ta) IgG<\/td><\/tr>
<\/td>Rekoveriini IgG<\/td><\/tr>
<\/td>Titiini IgG<\/td><\/tr>
<\/td>Yo IgG<\/td><\/tr>
<\/td>Amfif\u00fcsiini IgG<\/td><\/tr>
<\/td>Zic4 IgG<\/td><\/tr>
<\/td>Tr (DNER)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Ri<\/strong>-vastased IgG antikehad seonduvad keskn\u00e4rvis\u00fcsteemi neuronite tuumas oleva NOVA1 (Ri, 55 kDa) valguga.<\/p>\n\n\n\n

CV2 (CRMP5)<\/strong>-vastased IgG antikehad seonduvad oligodendrots\u00fc\u00fctide ts\u00fctoplasmas oleva CRMP5 valguga.<\/p>\n\n\n\n

Sox1<\/strong>-vastased IgG antikehad seonduvad Bergmanni gliia rakkude tuumas oleva SOX1 valguga.<\/p>\n\n\n\n

GAD65<\/strong>-vastased IgG antikehad seonduvad v\u00e4ikeaju granulaarses kihis oleva GAD65 valguga.<\/p>\n\n\n\n

Hu<\/strong>-vastased IgG antikehad seonduvad kesk- ja perifeerse n\u00e4rvis\u00fcsteemi neuronite tuumas olevate Hu-valkudega.<\/p>\n\n\n\n

PNMA-2 <\/strong>(Ma2\/Ta)<\/strong>-vastased IgG antikehad seonduvad neuronites ja munandites oleva PNMA2 valguga.<\/p>\n\n\n\n

Rekoveriini<\/strong>-vastased IgG antikehad seonduvad reetina fotoretseptorites oleva rekoveriini valguga.<\/p>\n\n\n\n

Titiini<\/strong>-vastased IgG antikehad seonduvad v\u00f6\u00f6tlihaste rakkudes oleva titiini valguga.<\/p>\n\n\n\n

Yo<\/strong>-vastased IgG antikehad seonduvad v\u00e4ikeaju Purkinje rakkude ts\u00fctoplasmas oleva Yo-antigeeniga.<\/p>\n\n\n\n

Amfif\u00fcsiini<\/strong>-vastased IgG antikehad seonduvad s\u00fcnaptiliste vesiikulite membraanil oleva amfif\u00fcsiin I valguga.<\/p>\n\n\n\n

Zic4<\/strong>-vastased IgG antikehad seonduvad neuronite tuumas, peamiselt v\u00e4ikeaju granulaarses kihis, oleva Zic4 valguga.<\/p>\n\n\n\n

Tr (DNER)<\/strong>-vastased IgG antikehad seonduvad v\u00e4ikeaju Purkinje rakkude ts\u00fctoplasmas oleva Tr-antigeeniga.<\/p>\n\n\n\n

Paraneoplastilisi neuroloogilisi s\u00fcndroome (PNS) seostatakse pahaloomuliste kasvajatega, kuid PNS teke ei ole otseselt p\u00f5hjustatud tuumorite, nende metastaaside, vaskulaarsete ja  infektsioossete tegurite v\u00f5i kasvajavastase teraapia poolt. PNS-i p\u00f5hjustab kasvajaseoseline immuunvastus, mille k\u00e4igus tekib ristreaktiivsus n\u00e4rvis\u00fcsteemile iseloomulike antigeenidega. See viib neuronite ja teiste n\u00e4rvis\u00fcsteemi struktuuride kahjustusteni, avaldudes kliiniliselt sageli primaarsest v\u00f5i metastaatilisest kasvajakoldest kaugemal. PNS-i esineb ligi 15% pahaloomuliste kasvajate korral, eriti kopsu- ja soolev\u00e4hi, aga ka rinna-, munasarja- ja eesn\u00e4\u00e4rmev\u00e4hi korral. PNS v\u00f5ib ilmneda enne kasvaja diagnoosimist (60\u201380%), samaaegselt kasvaja diagnoosimisega v\u00f5i selle foonil. Samuti v\u00f5ib PNS-i esineda autoimmuunhaiguste korral (nt I t\u00fc\u00fcpi diabeet).<\/p>\n\n\n\n

Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine<\/strong><\/p>\n\n\n\n

<\/td>Katsuti<\/td>Geeli ja h\u00fc\u00fcbimisaktivaatoriga katsuti (punane kollase r\u00f5ngagav\u00f5i kollane kork)<\/td><\/tr>
<\/td>S\u00e4ilivus<\/td>Seerum +4 \u00b0C 14 p\u00e4eva<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Anal\u00fc\u00fcsi tegemise aeg:<\/strong> kolm korda n\u00e4dalas<\/p>\n\n\n\n

Anal\u00fc\u00fcsimeetod:<\/strong> immunoblot-meetod (IB)<\/p>\n\n\n\n

Vastuse vorm:<\/strong> negatiivne\/positiivne<\/p>\n\n\n\n

IB meetodil saadud positiivne tulemus tuleb \u00fcle kinnitada teise s\u00f5ltumatu meetodiga (proovid saadetakse PERH laborisse, kus need anal\u00fc\u00fcsitakse kaudse immunofluorestsentsmeetodiga (IIF)). Kahel meetodil saadud positiivne tulemus annab l\u00f5pliku anal\u00fc\u00fcsivastuse.<\/p>\n\n\n\n

N\u00e4idustus ja kliiniline t\u00e4hendus<\/strong><\/p>\n\n\n\n

Paraneoplastiliste neuroloogiliste s\u00fcndroomide diagnostika.<\/p>\n\n\n\n

Tabel 1. Neuroloogiliste haiguste ning kasvajate seos PNS-i autoantikehadega.<\/strong><\/p>\n\n\n\n

<\/td> <\/strong><\/td>Neuroloogilised haigused<\/strong><\/td>Kasvajad<\/strong><\/td><\/tr>
<\/td>Ri IgG<\/strong><\/td>paraneoplastiline opsokloonus-m\u00fcokloonus ataksia (POMA), paraneoplastiline tserebellaarne degeneratsioon (PCD), rombentsefaliit<\/td>V\u00e4ikerakuline kopsuv\u00e4hk (SCLC), rinnav\u00e4hk, Hodgkini l\u00fcmfoom, mitte-Hodgkini l\u00fcmfoom, kiire kasvuga ajut\u00fcve kasvaja, munasarjav\u00e4hk<\/td><\/tr>
<\/td>CV2 (CRMP5) IgG<\/strong><\/strong><\/td>limbiline entsefaliit, PCD, pol\u00fcneuropaatia (autonoomne, sensoorne, sensomotoorne), retinopaata, uveiit, m\u00fcasteeniline s\u00fcndroom, krooniline gastrointestinaalne pseudoobstruktsioon, koorea, POMA, rombentsefaliit, fokaalne epilepsia<\/td>SCLC, t\u00fcmoom, emaka sarkoom<\/td><\/tr>
<\/td>Sox1 IgG<\/strong><\/strong><\/td>Lambert-Eatoni m\u00fcasteeniline s\u00fcndroom (LEMS), PCD<\/td>SCLC<\/td><\/tr>
<\/td>GAD65 IgG<\/strong><\/strong><\/td>Stiff person<\/em> s\u00fcndroom (SPS). V\u00f5ib esineda koos I t\u00fc\u00fcpi diabeediga.<\/td>SCLC, rinnav\u00e4hk, soolev\u00e4hk<\/td><\/tr>
<\/td>Hu IgG<\/strong><\/strong><\/td>ajut\u00fcve entsefaliidid v\u00e4ikeaju ja limbilise s\u00fcsteemi haaratusega, m\u00fceliit, pol\u00fcneuropaatia (autonoomne, sensoorne, sensomotoorne) PCD, ekstrap\u00fcramidaalsed motoorsed s\u00fcndroomid, POMA, LEMS, krooniline gastrointestinaalne pseudoobstruktsioon, retinopaatia<\/td>SCLC (80%), neuroblastoom, eesn\u00e4\u00e4rme, p\u00f5ie-, munasarja-, pankrease ja rinnav\u00e4hk, seedetrakti pahaloomulised kasvajad<\/td><\/tr>
<\/td>PNMA-2 IgG<\/strong><\/td>rombentsefaliit, PLE, ajut\u00fcve entsefalopaatia, POMA, PCD, ekstrap\u00fcramidaalsed motoorsed s\u00fcndroomid, retinopaata<\/td>munandi idurakuline kartsinoom (seminoom), mittev\u00e4ikerakuline kopsuv\u00e4hk, s\u00fcljen\u00e4\u00e4rme, rinna-, munasarja, j\u00e4mesoole ja neeruv\u00e4hk, l\u00fcmfoom<\/td><\/tr>
<\/td>Rekoveriini IgG<\/strong><\/strong><\/td>retinopaatia<\/td>SCLC<\/td><\/tr>
<\/td>Titiini IgG<\/strong><\/strong><\/td>Myasthenia gravis<\/em><\/td>t\u00fcmoom<\/td><\/tr>
<\/td>Yo IgG<\/strong><\/strong><\/td>PCD, POMA<\/td>munasarja-, rinna-, emakav\u00e4hk, s\u00f6\u00f6gitoru adenokartsinoom, sapip\u00f5ie, eesn\u00e4\u00e4rme v\u00e4hk, Hodgkini l\u00fcmfoom, mitte-Hodgkini l\u00fcmfoom, t\u00fcmoom<\/td><\/tr>
<\/td>Amfif\u00fcsiini IgG<\/strong><\/strong><\/td>Stiff person<\/em> s\u00fcndroom (SPS), m\u00fcasteeniline s\u00fcndroom, pol\u00fcneuropaatia (autonoomne, sensoorne, sensomotoorne), rigiidsusega kulgev entsefalom\u00fceliit, tserebellaarne ataksia, POMA<\/td>rinnav\u00e4hk, SCLC, t\u00fcmoom, Hodgkini l\u00fcmfoom, j\u00e4mesoolev\u00e4hk<\/td><\/tr>
<\/td>Zic4 IgG<\/strong><\/strong><\/td>tserebellaarne degeneratsioon<\/td>SCLC<\/td><\/tr>
<\/td>Tr(DNER) IgG<\/strong><\/td>tserebellaarne degeneratsioon, harva limbiline enstefaliit, entsefalopaatia, sensoorne neuropaatia<\/td>Hodgkini l\u00fcmfoom<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Neuronaalsete antigeenide IgG paneel (IB) ei ole sobilik GAD65-vastaste antikehade anal\u00fc\u00fcsimiseks diabeedi korral. Negatiivne tulemus neuronaalsete antigeenide IgG paneelil ei v\u00e4lista anti-GAD65 olemasolu.<\/p>\n\n\n\n

Vt ka Autoimmuunse diabeedi uuringud<\/p>\n\n\n\n

Koostajad: Anet Laanesoo, Ija Talja<\/p>\n\n\n\n

Koostatud: 17.04.2026<\/p>\n","protected":false},"excerpt":{"rendered":"

Immuunanal\u00fc\u00fcsi osakond Anal\u00fc\u00fcsid: Ri IgG CV2 (CRMP5) IgG Sox1 IgG GAD65 IgG Hu IgG  PNMA-2 (Ma2\/Ta) IgG Rekoveriini IgG Titiini IgG Yo IgG Amfif\u00fcsiini IgG Zic4 IgG Tr (DNER) Ri-vastased IgG antikehad seonduvad keskn\u00e4rvis\u00fcsteemi neuronite tuumas oleva NOVA1 (Ri, 55 kDa) valguga. CV2 (CRMP5)-vastased IgG antikehad seonduvad oligodendrots\u00fc\u00fctide ts\u00fctoplasmas oleva CRMP5 valguga. Sox1-vastased IgG antikehad […]<\/p>\n","protected":false},"author":31,"featured_media":0,"parent":7253,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-15578","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nNeuronaalsete antigeenide IgG paneel (IB) - \u00dchendlabor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/autoimmuunuuringud\/neuronaalsete-antigeenide-igg-paneel-ib\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuronaalsete antigeenide IgG paneel (IB) - \u00dchendlabor\" \/>\n<meta property=\"og:description\" content=\"Immuunanal\u00fc\u00fcsi osakond Anal\u00fc\u00fcsid: Ri IgG CV2 (CRMP5) IgG Sox1 IgG GAD65 IgG Hu IgG  PNMA-2 (Ma2\/Ta) IgG Rekoveriini IgG Titiini IgG Yo IgG Amfif\u00fcsiini IgG Zic4 IgG Tr (DNER) Ri-vastased IgG antikehad seonduvad keskn\u00e4rvis\u00fcsteemi neuronite tuumas oleva NOVA1 (Ri, 55 kDa) valguga. CV2 (CRMP5)-vastased IgG antikehad seonduvad oligodendrots\u00fc\u00fctide ts\u00fctoplasmas oleva CRMP5 valguga. 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