{"id":16016,"date":"2026-07-22T14:47:53","date_gmt":"2026-07-22T12:47:53","guid":{"rendered":"https:\/\/www.kliinikum.ee\/yhendlabor\/?page_id=16016"},"modified":"2026-07-22T15:01:51","modified_gmt":"2026-07-22T13:01:51","slug":"gangliosiidide-vastase-igg-paneel-gangliosiidide-vastase-igm-paneel","status":"publish","type":"page","link":"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/autoimmuunuuringud\/gangliosiidide-vastase-igg-paneel-gangliosiidide-vastase-igm-paneel\/","title":{"rendered":"Gangliosiidide vastase IgG paneel, gangliosiidide vastase IgM paneel"},"content":{"rendered":"\n

Immuunanal\u00fc\u00fcsi osakond<\/em><\/p>\n\n\n\n

Anal\u00fc\u00fcsid:<\/p>\n\n\n\n

<\/td>Gangliosiidide vastase IgG paneel:<\/td>Gangliosiidide vastase IgM paneel:<\/td><\/tr>
<\/td>GM1 IgG<\/td>GM1 IgM<\/td><\/tr>
<\/td>GM2 IgG<\/td>GM2 IgM<\/td><\/tr>
<\/td>GM3 IgG<\/td>GM3 IgM<\/td><\/tr>
<\/td>GD1a IgG<\/td>GD1a IgM<\/td><\/tr>
<\/td>GD1b IgG<\/td>GD1b IgM<\/td><\/tr>
<\/td>GT1b IgG<\/td>GT1b IgM<\/td><\/tr>
<\/td>GQ1b IgG<\/td>GQ1b IgM<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Gangliosiidid kuuluvad gl\u00fckosfingolipiidide hulka ning moodustavad ~6% kogu n\u00e4rvis\u00fcsteemi lipiididest. Gangliosiidid omavad rolli rakuliiduste tekkel, neuronaalsel informatsiooni \u00fclekandel ja n\u00e4rvirakkude \u00e4ratundmisel immuuns\u00fcsteemi poolt. Autoimmuunse pol\u00fcneuropaatia (PNP) korral v\u00f5ivad tekkida immuuns\u00fcsteemis autoantikehad gangliosiidide struktuuri vastu.<\/p>\n\n\n\n

PNP saab jaotada j\u00e4rgnevalt:<\/p>\n\n\n\n

    \n
  1. GM1 vastased IgG antikehad. Seostatakse akuutse pol\u00fcradikuloneuriidi ehk hulgin\u00e4rvi p\u00f5letikuga. Eristatavad on Guillain-Barr\u00e9 s\u00fcndroom (GBS), akuutne dem\u00fceliniseeriv pol\u00fcradikuloneuropaatia (AIDP), akuutne motoorne aksonaalne neuropaatia (AMAN) ja akuutne motoorne sensoorne aksonaalne neuropaatia (AMSAN). Lisaks GM1 vastastele antikehadele v\u00f5ib esineda GD1a, GD1b ja GT1b vastaseid antikehasid.<\/li>\n\n\n\n
  2. GM1 vastased IgM antikehad esinevad kroonilise p\u00f5letikulise dem\u00fceliniseeriva PNP korral nagu multifokaalne motoorne neuropaatia (MMN), krooniline p\u00f5letikuline dem\u00fceliniseeriv PNP (CIDP), motoorne neuropaatia koos monoklonaalse IgM gammopaatiaga.<\/li>\n\n\n\n
  3. GQ1b vastaseid IgG antikehi seostatakse Miller-Fisher s\u00fcndroomiga (MFS), lisaks v\u00f5ivad esineda GD1b ja GT1b vastased IgG antikehad.<\/li>\n\n\n\n
  4. GD1b, GT1b, GQ1b vastased IgM antikehad v\u00f5ivad esineda CANOMAD s\u00fcndroomi korral.<\/li>\n<\/ol>\n\n\n\n

    Soovituslik on tellida korraga nii gangliosiidide vastase IgM kui ka gangliosiidide vastase IgG paneel, kuid neid saab tellida ka eraldi.<\/p>\n\n\n\n

    Uuritav materjal, selle v\u00f5tmine, saatmine ja s\u00e4ilitamine<\/strong><\/p>\n\n\n\n

    <\/td>Katsuti<\/td>Geeli ja h\u00fc\u00fcbimisaktivaatoriga katsuti (punane kollase r\u00f5ngaga v\u00f5i kollane kork)<\/td><\/tr>
    <\/td>S\u00e4ilivus<\/td>Seerum +4 \u00b0C 14 p\u00e4eva<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    Anal\u00fc\u00fcsi tegemise aeg: <\/strong>kord n\u00e4dalas<\/p>\n\n\n\n

    Anal\u00fc\u00fcsimeetod: <\/strong>immunoblot<\/em>-meetod (IB)<\/p>\n\n\n\n

    Vastuse vorm<\/strong><\/p>\n\n\n\n

    Positiivne\/negatiivne (iga \u00fcksiku antikeha kohta eraldi).<\/p>\n\n\n\n

    N\u00e4idustus ja kliiniline t\u00e4hendus<\/strong><\/p>\n\n\n\n

    Kahtlus autoimmuunsele pol\u00fcneuropaatiale. Gangliosiidide vastaste IgG ja IgM antikehade m\u00e4\u00e4ramine aitab diagnoosida ja eristada autoimmuunse pol\u00fcneuropaatia vorme (Tabel 1).<\/p>\n\n\n\n

    Tabel 1. Autoimmuunse pol\u00fcneuropaatia vormid ja nendele iseloomulik antikehade esinemine. Peamine reaktiivsus on v\u00e4lja toodud rasvaselt, lisaks v\u00f5ib esineda ristreaktiivsust muude gangliosiididega (Conrad jt. 2017)<\/p>\n\n\n\n

    <\/td> <\/td>GM1<\/strong><\/td>GM2<\/strong><\/td>GM3<\/strong><\/td>GD1a<\/strong><\/td>GD1b<\/strong><\/td>GT1b<\/strong><\/td>GQ1b<\/strong><\/td><\/tr>
    <\/td>GBS\/AIDP<\/td>IgG>IgM<\/strong><\/td> <\/td> <\/td>IgG<\/td>IgG<\/td>IgG<\/td> <\/td><\/tr>
    <\/td>GBS\/AMAN, AMSAN<\/td>IgG<\/strong><\/td> <\/td> <\/td>IgG<\/strong><\/td>IgG<\/td>IgG<\/td> <\/td><\/tr>
    <\/td>GBS ts\u00fctomegaloviiruse infektsiooni j\u00e4rgselt<\/td>IgM<\/td>IgM<\/strong><\/td> <\/td>IgM<\/td>IgM<\/td> <\/td> <\/td><\/tr>
    <\/td>GBS ataksiaga<\/td> <\/td> <\/td> <\/td> <\/td>IgG<\/strong><\/td> <\/td>IgG<\/strong><\/td><\/tr>
    <\/td>GBS orofar\u00fcngeaalsete, kaela-, ja \u00f5lalihaste halvatusega<\/td>IgG<\/td> <\/td> <\/td>IgG<\/strong><\/td> <\/td> <\/td>IgG<\/strong><\/td><\/tr>
    <\/td>GBS oftalmopleegiaga<\/td> <\/td> <\/td> <\/td> <\/td> <\/td> <\/td>IgG<\/strong><\/td><\/tr>
    <\/td>MFS<\/td> <\/td> <\/td> <\/td> <\/td>IgG<\/td>IgG<\/td>IgG<\/strong><\/td><\/tr>
    <\/td>Bickerstaffi entsefaliit<\/td> <\/td> <\/td> <\/td> <\/td> <\/td> <\/td>IgG<\/strong><\/td><\/tr>
    <\/td>CANOMAD<\/td> <\/td> <\/td>IgM<\/td>IgM<\/td>IgM<\/strong><\/td>IgM<\/strong><\/td>IgM<\/strong><\/td><\/tr>
    <\/td>MMN<\/td>IgM<\/strong><\/td>IgM<\/td>IgM<\/td>IgM<\/td>IgM<\/td> <\/td> <\/td><\/tr>
    <\/td>CIDP<\/td>IgM<\/td>IgM<\/td>IgM<\/td>IgM<\/td>IgM<\/td> <\/td> <\/td><\/tr>
    <\/td>Motoorne neuropaatia koos monoklonaalse IgM gammopaatiaga<\/td>IgM<\/strong><\/td> <\/td> <\/td> <\/td>IgM<\/strong><\/td> <\/td> <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    <\/p>\n\n\n\n

    Kasutatud kirjandus: Conrad K., Sch\u00f6\u00dfler W., Hiepe F., Fritzler M.J. (2011). Autoantibodies in Organ Specific Autoimmune Diseases. A Diagnostic Reference, vol. 8, lk 67. Lengerich: Pabst Science Publishers.<\/p>\n\n\n\n

    Koostaja: Anet Laanesoo<\/p>\n\n\n\n

    Koostatud 02.07.2026<\/p>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Immuunanal\u00fc\u00fcsi osakond Anal\u00fc\u00fcsid: Gangliosiidide vastase IgG paneel: Gangliosiidide vastase IgM paneel: GM1 IgG GM1 IgM GM2 IgG GM2 IgM GM3 IgG GM3 IgM GD1a IgG GD1a IgM GD1b IgG GD1b IgM GT1b IgG GT1b IgM GQ1b IgG GQ1b IgM Gangliosiidid kuuluvad gl\u00fckosfingolipiidide hulka ning moodustavad ~6% kogu n\u00e4rvis\u00fcsteemi lipiididest. Gangliosiidid omavad rolli rakuliiduste tekkel, neuronaalsel […]<\/p>\n","protected":false},"author":31,"featured_media":0,"parent":7253,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-16016","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nGangliosiidide vastase IgG paneel, gangliosiidide vastase IgM paneel - \u00dchendlabor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kliinikum.ee\/yhendlabor\/kasiraamat\/autoimmuunuuringud\/gangliosiidide-vastase-igg-paneel-gangliosiidide-vastase-igm-paneel\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gangliosiidide vastase IgG paneel, gangliosiidide vastase IgM paneel - \u00dchendlabor\" \/>\n<meta property=\"og:description\" content=\"Immuunanal\u00fc\u00fcsi osakond Anal\u00fc\u00fcsid: Gangliosiidide vastase IgG paneel: Gangliosiidide vastase IgM paneel: GM1 IgG GM1 IgM GM2 IgG GM2 IgM GM3 IgG GM3 IgM GD1a IgG GD1a IgM GD1b IgG GD1b IgM GT1b IgG GT1b IgM GQ1b IgG GQ1b IgM Gangliosiidid kuuluvad gl\u00fckosfingolipiidide hulka ning moodustavad ~6% kogu n\u00e4rvis\u00fcsteemi lipiididest. 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Gangliosiidid omavad rolli rakuliiduste tekkel, neuronaalsel…","_links":{"self":[{"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/pages\/16016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/comments?post=16016"}],"version-history":[{"count":3,"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/pages\/16016\/revisions"}],"predecessor-version":[{"id":16022,"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/pages\/16016\/revisions\/16022"}],"up":[{"embeddable":true,"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/pages\/7253"}],"wp:attachment":[{"href":"https:\/\/www.kliinikum.ee\/yhendlabor\/wp-json\/wp\/v2\/media?parent=16016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}