Hoolivus, Uuendusmeelsus, Pädevus ja Usaldusväärsus
Glomeeruli basaalmembraani vastane IgG (S-GBMA IgG)
Immuunanalüüsi osakonna autoimmuniteedi grupp, tel. 737 4240
Glomeeruli basaalmembraani vastase IgG sihtantigeeniks on glomeerulite basaalmembraani koostises oleva 4. tüüpi kollageeni kolm alfa-ahelat, mis moodustavad mitmeid erinevaid domeene. NC1 domeen on peamine antikehade seostumise koht.
Uuritav materjal, selle võtmine, saatmine ja säilitamine
Saatelehena tuleb kasutada Ühendlabori autoantikehade uuringu vormi (vt Saatelehed), mille kõik väljad peavad olema korrektselt täidetud.
Katsuti
Geeli ja hüübimisaktivaatoriga katsuti (kollane kork)
GBMA IgG esinemine on seotud kiiresti progresseeruva glomerulonefriidiga, peamiselt anti-GBM glomerulonefriidi ja Goodpasture’i sündroomiga (antikehi esineb 80–90% patsientidest). Harva leitakse neid autoantikehi kopsu hemorraagiaga patsientidel, kellel glomerulonefriiti ei kaasu.
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