Glomeeruli basaalmembraani vastane IgG (S-GBMA IgG)
Immuunanalüüsi osakond
Glomeeruli basaalmembraani vastase IgG sihtantigeeniks on glomeerulite basaalmembraani koostises oleva 4. tüüpi kollageeni kolm alfa-ahelat, mis moodustavad mitmeid erinevaid domeene. NC1 domeen on peamine antikehade seostumise koht.
Uuritav materjal, selle võtmine, saatmine ja säilitamine
Katsuti
Geeli ja hüübimisaktivaatoriga katsuti (kollane kork)
GBMA IgG esinemine on seotud kiiresti progresseeruva glomerulonefriidiga, peamiselt anti-GBM glomerulonefriidi ja Goodpasture’i sündroomiga (antikehi esineb 80–90% patsientidest). Harva leitakse neid autoantikehi kopsu hemorraagiaga patsientidel, kellel glomerulonefriiti ei kaasu.
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