Atsetüülkoliini retseptori vastased antikehad on seerumis esinevad autoantikehad (acethylcholine receptor autoantibodies, AChR Ab), mille sihtantigeeniks on atsetüülkoliini retseptori erinevad alaühikud.
Uuritav materjal, selle võtmine, saatmine ja säilitamine
Katsuti
Geeli ja hüübimisaktivaatoriga katsuti (kollane kork)
Säilivus
Seerum +4 °C 14 päeva, -20 °C kaks kuud
Analüüsi tegemise aeg: kaheksa uuritava kogunemisel
Veres esinevad AchR antikehad umbes 85%-l myasthenia gravis’e (MG) generaliseerunud vormiga patsientidest. Antikehade tase võib olla kergelt tõusnud amüotroofilise lateraalskleroosi, polümüosiidi, primaarse biliaarse tsirroosi ja tümoomiga patsientidel ning penitsillamiinravi saanud reumatoidartriidi haigetel. MG haigetel võib antikehade hulk olla väga erinev. Ei ole leitud selget seost antikehade taseme ja haiguse aktiivsuse vahel. Samas korrelleerub antikehade taseme 50%-line langus ka kliinilise paranemisega.
Umbes 15%-l MG patsientidest ei ole veres määrataval tasemel AChR antikehi, kuigi nad reageerivad immunosupressiivsele ravile.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
