Neerupealise koore vastased IgG antikehad on seerumis esinevad autoantikehad (anti-adrenocortical antibodies, AAA IgG), mille sihtantigeenid on tsütokroom P450 steroidogeensed ensüümid, peamiselt 21-hüdroksülaas.
Uuritav materjal, selle võtmine, saatmine ja säilitamine
Katsuti
Geeli ja hüübimisaktivaatoriga katsuti (punane kollase rõngaga või kollane kork)
Addisoni tõve ja autoimmuunsete (eriti ovariaalfunktsiooni häiretega kaasnevate) polüendokrinopaatiate diagnostika, samuti nimetatud haiguste tekke riski hindamine haigete lähisugulastel ja insuliinsõltuva diabeedi (IDDM) ehk 1. tüüpi diabeedi ning autoimmuunse türeoidiidiga patsientidel.
Neerupealise koore vastased antikehad on kõrge spetsiifilisusega autoimmuunse Addisoni tõve ning autoimmuunsete polüglandulaarsündroomide(APS I ja APS II) markerid. Need esinevad 20–80% Addisoni tõve juhtudest, kusjuures antikehade leidumine on tõenäolisem kaasneva polüglandulaarsündroomi korral (APS I puhul 60–80%, APS II puhul 25–40%). Primaarse autoimmuunse ovariaalpuudulikkusega Addisoni tõve haigetel leitakse neerupealise koore antikehi kuni 100% uuritutest. Nendel antikehadel on ka prognostiline tähendus. On võimalik, et antikehade teke eelneb kliiniliselt manifesteerunud haigusele.
Koostaja: Anet Laanesoo, Kaja Metsküla Muudetud 27.04.2026
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